Negative regulation of EGFR-Vav2 signaling axis by Cbl ubiquitin ligase controls EGFR-mediated epithelial cell adherens junction dynamics and cell migration

Negative regulation of EGFR-Vav2 signaling axis by Cbl ubiquitin ligase controls EGFR-mediated epithelial cell adherens junction dynamics and cell migration Lei Duan*, Srikumar M. Raja*, Gengsheng Chen, Sumeet Virmani, Stetson H. Williams, Robert J. Clubb, Chandrani Mukhopadhyay, Mark A. Rainey, Guoguang Ying, Manjari Dimri, Jing Chen, Alagarsamy L. Reddi, Mayumi Naramura, Vimla Band, Hamid Band* Eppley Institute for Cancer and Allied Diseases, and Departments of Biochemistry & Molecular Biology, Pathology & Microbiology, Pharmacology & Neuroscience, and Genetics, Cell Biology & Anatomy, College of Medicine, University of Nebraska Medical Center, 985950 Nebraska Medical Center, Omaha, NE 68198-5950 Current addresses: GC: Coskata Energy, Warrenville, IL; SV: Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, IL; RJC: Genzyme Genetics, Westborough, MA 01581; GY: Tianjin Hospital and Cancer Institute, Tianjin Medical University, West HuanHu Road, HeXi District, Tianjin, P.R.China; MD: Department of Biochemistry, George Washington University School of Medicine, Washington DC; JC: Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL; ALR: Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL; LD: Department of Radiation Oncology, Rush University Medical Center, 1750 W Harrison St, Chicago, IL60612; *Address correspondence to: Lei Duan, Rush University Medical Center, 1750 W Harrison St, Chicago, or Srikumar M. Raja or Hamid Band, MD, Ph.D., Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 985950 Nebraska Medical Center, Omaha, NE 68198-5950; E-mail: [email protected]; [email protected]; [email protected].